同济大学学报（医学版）2012，Vol.33Issue(1)：105-109,5.DOI:10.3969/j.issn1008-0392.2012.01.023
Wnt/β-catenin和EGFR信号通路在非小细胞肺癌发生发展中的作用
Wnt/β-catenin and EGFR signaling pathway in carcinogenesis and progression of non-small cell lung cancer
摘要
Abstract
Wnt/p-catenin and EGFR signaling pathway are crucial in embryogenesis, tumor formation and progression. Studies have shown that Wntl and Wnt5a can activate EGFR signal pathway in mammary tumor; overexpression of EGFR in lung cancer can promote the accumulation of p-catenin in nucleus. It is indicated that cross-communication may exist between two pathways. This article reviews recent research advances in the function and cross-talking of these two pathways in non-small cell lung cancer.关键词
肺肿瘤/非小细胞肺肿瘤/Wnt/β-catenin/EGFR/交叉通路Key words
pulmonary carcinoma/ non-small cell lung cancer/ Wnt/fS-catenin/ EGFR/ cross-talking/分类
医药卫生引用本文复制引用
方霞..Wnt/β-catenin和EGFR信号通路在非小细胞肺癌发生发展中的作用[J].同济大学学报（医学版）,2012,33(1):105-109,5.基金项目
上海市科学技术委员会科研基金(034119868) （034119868）
上海市科学技术委员会医学重点科研基金(09411951600) （09411951600）
