陕西医学杂志2012，Vol.41Issue(3)：289-291,294,4.
降钙素对兔膝骨性关节炎关节软骨细胞凋亡及NO含量的影响
Effects of calcitonin on apoptosis of articular cartilage and the changes of NO in rabbits with knee osteoarthritis
摘要
Abstract
Objective:To study the effects of Calcitonin on apoptosis of articular cartilage and the changes of NO in rabbits with knee osteoarthritis. Methods:36 rabbits were randomly divided into three groups: normal group (group A) , model group (group B)and CT treatment group (group C). There were 12 rabbits in each group. The rabbits in group B and C were made into knee osteoarthritis by Hulth's method. The rabbits in group A weren't dealed by special process, except for incision of skin and articular cavity. The rabbits in group C were interfered by hypodermic injection CT everyday(5U/ kg). The other rabbits were interfered by normal saline. The pathomorphism and apoptosis of articular cartilage, the changes of NO in serum and synovial fluid were observed. Results-.The scores of JP and Mankin in group B were significantly higher than those in group A, articular cartilage injury was more serious, meanwhile, the apoptotic percent of articular cartilage and the content of NO in serum and synovial fluid increased too. Compared with group B, the scores of JP and Man-kin in group C were significantly decreased, the articular cartilage injury reduced evidently, the apoptotic percent of articular cartilage and the content of NO in serum and synovial fluid decreased significantly. Conclusion :CT may reduce articular cartilage injury of KOA by downregulating of NO.关键词
骨关节炎,膝/病理生理学/细胞凋亡/降钙素/代谢/一氧化氮/分析/兔Key words
Osteoarthritis, Knee/physiopathology/Apoptosis/Calcitonin/metabolism/Nitric oxide/analysis Rabbits分类
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尤笑迎..降钙素对兔膝骨性关节炎关节软骨细胞凋亡及NO含量的影响[J].陕西医学杂志,2012,41(3):289-291,294,4.
