陕西医学杂志2012，Vol.41Issue(5)：611-613,3.
抗中性粒细胞胞浆抗体相关性小血管炎60例免疫学指标分析
Immunological parameters in patients with antineutrophil cytoplasmic autoantibody-associated systemic vasculitis
摘要
Abstract
Objective: To investigate the changes in the immunological parameters in patients with anti-ncutrophil cytoplasmic autoantibody-associatcd systemic vasculitis(AASV) and the relationship with therapeutic efficacy in the near future. Methods: 60 patients with AASV were selected in the study, anti-ncutrophil cytoplasmic antibodies (ANCA) and its target antigcns-Protcinasc 3 and myciopcroxidasc were measured by the modus of indirect immunofluorcsccncc method and enzyme-linked immunosorbent assay (KLISA). CRP was determined by immuno-turbidimctry. Results; In clinic, the patients with P-ANCA were always with longer duration (P<C_0. 01). Compared with normal control group, ANCA and its target antigens were significantly increased (P<C0. 001) , and CRP also elevated significantly (P<0. 001). To compare with PR3 and MPO, CRP level was decreased in the 19 patients who were diagnosed as AASV after the treatment of 6 -12 weeks (P<0. 001). Conclusion; ANCA and its target antigens have higher specificity in the diagnosis of AASV. For the antibody is always with long duration in the body, it can not be the appropriate marker for the mitigation and prognosis of AASV. Endothclial dysfunction in patients with inflammatory change caused the alteration of CRP level. Compared with the control group, CRP in the inflammatory group significantly increased, and with remission and partial remission the level decreased.关键词
血管炎/免疫学/抗体,抗中性白细胞胞质/代谢/过氧化物酶/代谢/酶联免疫吸附测定Key words
Vasculitis/immunology Antibodies/ antincutrophil cytoplasmic/mctabolism/ Pcroxi-dasc/mctabolism/ Enzyme-linked imunosorbent assay分类
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邢娜,姚智..抗中性粒细胞胞浆抗体相关性小血管炎60例免疫学指标分析[J].陕西医学杂志,2012,41(5):611-613,3.
