实用医学杂志2012，Vol.28Issue(5)：711-714,4.DOI:10.3969/j.issn.1006-5725.2012.05.009
热休克联合缺血预处理对大鼠心肌缺血再灌注损伤早期的保护作用研究
The research of protection of intervention on early MIRI for the heat shock combined IPC in rats
摘要
Abstract
Objective To explore whether the heat shock(HS) combined classic ischemic preconditioning (IPC) has superimposed protection against myocardial ischemia-reperfusion injury (MIRI) early in rats. Methods 50 Wistar rats were randomly divided into 5 groups: SO group, MIRI group, classic IPC group, HS group, HS + IPC group. The MIRI model was established by ligating left coronary artery. After pretreatment, the hemodynamic parameters were dynamic monitored; the plasma SOD, MDA and CK-MB were determinated, the pathological changes of myocardial tissue were observed under light microscope. Results Compared with HS or classic IPC group, the LVEDP was decreased (P < 0.05), the CK-MB was also decreased (P < 0.05) in HS + IPC group after irrigation; the MDA reduced, SOD increased in HS + IPC group were similar with HS group, but better than classic IPC group (P< 0.05). Conclusion Heat shock combined classic IPC intervention might have certain superimposed protection against the MIRI early.关键词
心肌再灌注损伤/热休克/缺血预处理,心肌/心肌保护/大鼠Key words
Myocardial reperfusion injury/Heat shock/Ischemic preconditioning,myocardial/Myocardial protection/Rats引用本文复制引用
汪晓筠,谢智,王建新,马祁生..热休克联合缺血预处理对大鼠心肌缺血再灌注损伤早期的保护作用研究[J].实用医学杂志,2012,28(5):711-714,4.基金项目
青海大学医学院中青年基金资助项目(编号:QY-2008-10) （编号:QY-2008-10）
