实用医学杂志2012，Vol.28Issue(5)：726-728,3.DOI:10.3969/j.issn.1006-5725.2012.05.014
无精子症患者精浆高迁移率族蛋白B1检测的临床意义
Clinical significance of high mobility group box 1 detection in seminal plasma
摘要
Abstract
Objective To investigate the clinical significance of high mobility group box 1 (HMGB1) and C-reactive protein in seminal plasma in male sterility. Methods The levels of HMGB1 in seminal plasma of 61 infertile men (including 18 aspermias) and normal 20 males were detected by ELISA. The levels of C -reactive protein were detected with nephelometry immunoassay. Results The level of HMGB1 (22.68 ± 4.45)μg/L and C-reactive protein (33.71 ± 6.96)mg/L in seminal plasma of 18 aspermias were significantly higher than that in normal males [(12.88±6.84)μg/L;(1.73 ±0.78)mg/L] and other infertile men [(14.68 ± 8.25)μg/L; (2.34 ± 1.78)mg/L]. The correlation coefficient was 0.97 between HMGB1 and C-reactive protein levels of seminal plasma in aspermias. Conclusion The level of HMGB1 is significantly elevated in seminal plasma of aspermias, which may be related with its inflammatory response.关键词
不育/精液/高迁移率族蛋白B1Key words
Infertility/Semen/High mobility group box 1引用本文复制引用
吴国荣,周德琪,李蕾,李琴,尹丽,陈国千..无精子症患者精浆高迁移率族蛋白B1检测的临床意义[J].实用医学杂志,2012,28(5):726-728,3.基金项目
国家自然科学基金资助项目(编号:81070074) （编号:81070074）
