实用医学杂志2012，Vol.28Issue(5)：728-730,3.DOI:10.3969/j.issn.1006-5725.2012.05.015
血清胸苷激酶1在乳腺癌诊治中的应用
The application study on serum thymidine kinase 1 level changes for diagnosis and therapy of breast cancer
摘要
Abstract
Objective To evaluate the serum thymidine kinase 1 (TK1) as a tumor marker for early tumor detection and monitoring chemotherapy effect on breast cancer patients. Methods 20 healthy volunteers, 30 patients with breast cancer before or after operation and chemotherapy were detected the levels of serum TK1 by western blot. Comparing the different levels of TK1 with breast cancer under the different stages. The relationship of TK1 levels with the estrogen receptor (ER) and progesterone receptor (PR) was analyzed. Results The TK1 levels in the patients with breast cancer were significantly higher than control groups (P < 0.05). The TK1 levels in the patients with breast cancer after chemotherapy were significantly lower than before operation (P < 0.05), but the TK1 levels in the cases with breast cancer before or after operation had no difference (P > 0.05), and the TK1 levels had no obvious related with breast cancer stages (P > 0.05). The TK1 levels in patients with both ER and PR positive were lower than that in patients with both negative (P< 0.05). Conclusions The TK1 levels can reflect cell proliferation, and may serve as an important indictor for pathogenetic condition monitor and prognosis in breast cancer. But the precisemechanism and the relationship of the TK1 expression with the neoplasm progress need further study.关键词
乳腺肿瘤/血清胸苷激酶/诊断Key words
Breast cancer/Serum thymidine kinase 1/Diagnosis引用本文复制引用
陈曲波,黎翠翠,赵蓉,戴燕,陈前军,陈炜烨..血清胸苷激酶1在乳腺癌诊治中的应用[J].实用医学杂志,2012,28(5):728-730,3.基金项目
广东省科技厅社会发展计划资助项目(编号:2008B060600042) （编号:2008B060600042）
