实用医学杂志2012，Vol.28Issue(5)：731-733,3.DOI:10.3969/j.issn.1006-5725.2012.05.016
促血管生成素-2与胎儿生长受限发病的关系
Relationship between angiopietion-2 and fetal growth restriction
摘要
Abstract
Objective To investigate the levels of angiopietion-2 (Ang-2) in maternal serum and umbilical cord serum and the expression of Ang-2 in placenta from fetal growth restriction (FGR) patients, and to evaluate their relationships with FGR. Methods We selected 30 pregnant women being cesarean section in hospital with FGR as experimental group and 30 normal term pregnant women because of social factors terminating pregnancy as control group. The levels of Ang-2 in maternal serum and umbilical cord serum were detected by solid phrase sandwich enzyme linked immune sorbent assay (ELISA). The expression Ang-2 in placenta were detected by immunohistochemistry (SP). Results (l)The levels of Ang-2 in maternal serum and in umbilical cord serum and the expression Ang-2 in placenta were significantly lower in experimental group than in the control group. [(8.86 ± 0.43)ng/mL vs. (19.31 ± 0.25)ng/mL and (10.92 ± 0.41) ng/mL vs. (22.28 ± 0.23)ng/mL, (118.17 ± 1.59) vs. (151.64 ± 1.64), P< 0.01]. (2)The expression of Ang-2 in placenta were positively correlated to the levels in maternal serum in experimental group ( r = 0.93, P < 0.01). The expression of Ang-2 in placenta were positively correlated to the levels in umbilical cord serum in experimental group (r = 0.93, P < 0.01). The levels in maternal serum in experimental group were positively correlated to the levels in umbilical cord serum in experimental group ( r = 0.99, P < 0.01). Conclusion The levels of Ang-2 in maternal serum and in umbilical cord serum and the expression of Ang-2 in placenta decrease significantly, which may be related to the pathogenesis of FGR.关键词
胎儿生长迟缓/促血管生成素-2Key words
Fetal growth retardation/Angiopietion-2引用本文复制引用
程国梅,管秀娟,张婷,崔世红,刘萍萍..促血管生成素-2与胎儿生长受限发病的关系[J].实用医学杂志,2012,28(5):731-733,3.基金项目
河南省教育厅自然科学研究计划项目(编号:2010A320021) （编号:2010A320021）
