实用医学杂志2012，Vol.28Issue(6)：913-915,3.DOI:10.3969/j.issn.1006-5725.2012.06.019
尿肾损伤分子-1水平变化与狼疮肾炎合并肾功能不全患者预后的关系
Relationship between urinary kidney injury molecule-1 changes and prognosis in patients with lupus nephritis and renal insufficiency
摘要
Abstract
Objective To investigate urinary kidney injury molecule-1 (KIM-1) changes and its significance in lupus nephritis (LN) patient with renal insufficiency (RI). Methods Thirty-one LN patients admitted to our hospital were enrolled and divided into normal renal function group (Group A), RI with improved renal function group (Group B) , RI with unimproved renal function group (Group C). The level of serum creatinine (SCr), urinary KIM-1 were detected. We compared the changes of urinary KIM-land its correlation with estimated glomerular filtration rate (eGFR) and value in determining prognosis. Results After admission, urinary KIM-1 of three groups were markedly increased (P < 0.05), with the most significantly increase in group B (P < 0.001). After 14 days, urinary KIM-1 were significantly decreased in group B (P < 0.05). Urinary KIM-1 was negatively correlated with eGFR (r = -0.385, P= 0.048). By ROC curve analysis, urinary KIM-1, NAG, GAL and SCr levels predicted the improvement of renal function in LN patients, and showed that the area under the curve were 0.93、0.86、0.77、0.57. Conclusions The level of urinary KIM-1 increased significantly in LN and RI patient whose renal function would improve in 14 days, and decreased accompanied by the improvement of renal function after treatment. Urinary KIM-1 may be very important for the prognosis in LN patients.关键词
狼疮肾炎/肾功能不全/肾损伤分子-1Key words
Lupus nephritis/ Renal insufficiency/ Kidney injury molecule-1引用本文复制引用
姚瑶,林珊,贾俊亚,袁鲁晓..尿肾损伤分子-1水平变化与狼疮肾炎合并肾功能不全患者预后的关系[J].实用医学杂志,2012,28(6):913-915,3.基金项目
国家自然科学基金资助项目(编号:30800529) （编号:30800529）
天津市应用基础及前沿计划(编号:10JCYBJC11700) （编号:10JCYBJC11700）
