生殖医学杂志2012，Vol.21Issue(1)：73-77,5.DOI:10.3969/j.issn.1004-3845.2012.01.021
胎盘发育及功能评价的研究进展
Research advances in development and function of villous placenta
吕芳 1王丽丽 2贺斌 1王介东2
作者信息
- 1. 北京协和医学院研究生院,北京100730
- 2. 国家人口计生委科学技术研究所,北京 100081
- 折叠
摘要
Abstract
The fetus survival and growth are critically dependent on the placenta during gestation. The dysfunction of placenta will result in fetal growth restriction or, if more severe, fetal death. Invasion and fusion of trophoblast cells and vascular modification during placental development contribute to efficient substance exchange between maternal and fetal circulatory systems. Aberrant trophoblast proliferation and differentiation, incomplete trophoblast invasion to uterine wall, and abnormal fusion of mononucleated cytotrophoblasts with the overlying syncytiotrophoblast will affect the placenta development and transportation of nutrients. Earlier diagnosis of placental pathological changes by using biomarkers could facilitate the improvement of pregnancy outcomes. Angiogenic factors, placental hormones, and placental key functional genes are clinically used as biomarkers for diagnosis. This review focused on the up-to-date progress in placental morphology, function, hormonal secretion and biomarkers for earlier diagnosis of placental pathological changes.关键词
胎盘发育/滋养层细胞/胎盘功能障碍/分子标志物/先兆子痫Key words
Placental development/Cytotrophoblast cells/Placental dysfunction/Biomarkers/Preeclampsia引用本文复制引用
吕芳,王丽丽,贺斌,王介东..胎盘发育及功能评价的研究进展[J].生殖医学杂志,2012,21(1):73-77,5.
