天津科技大学学报2012，Vol.27Issue(1)：18-22,43,6.
大豆黄酮对衰老小鼠脑组织氧化损伤的调节
Regulation of Daidzein on Oxidative Damage Levels in the Brain of Aged Mice
摘要
Abstract
To observe the effects of daidzein on D-galactose induced senescence mice, D-galactose was for 6 weeks injected into the dorsal of mice as aged models. The aged mice were fed with different doses (5,10mg/(kg-d))of daidzein for 5 weeks. Y-maze was tested and the levels of synatophysin,reactive oxygen species,malondialdehyde.lipofuscin, and 8-hydroxy deoxyguanosine in brain were examined. The results showed that daidzein could increase Y-maze memory ability and the synatophysin level in the cortex, decrease reactive oxygen species and 8-hydroxy deoxyguanosine levels in the cortex and hippocampus of the aged mice, and also decrease the malondialdehyde and lipofuscin levels in brain tissues. Daidzein could increase memory ablility and decrease oxidative damage of the mice's brain. Daidzein could antisenesce in some degree.关键词
大豆黄酮/抗衰老/D-半乳糖/Y-谜宫/脑/氧化损伤Key words
daidzein/ antisenescence/ D-galactose/ Y-maze/ brain/ oxidative damage分类
生物科学引用本文复制引用
才金玲,单群,陆军,郑元林..大豆黄酮对衰老小鼠脑组织氧化损伤的调节[J].天津科技大学学报,2012,27(1):18-22,43,6.基金项目
天津科技大学引进人才科研启动基金资助项目(20100410) （20100410）
国家自然科学基金资助项目(1000050111) （1000050111）
