同位素2011，Vol.24Issue(z1)：80-84,5.
18F-FLT MicroPET评估顺铂对A549肺癌早期疗效反应的研究
18F-FLT MicroPET Imaging of Early Anti-tumor Response to Cisplatin on Lung Cancer
摘要
Abstract
In order to investigate the feasibility of 18F-FLT MicroPET in the early efficacy of the antineoplastic drug. Twelve A549 lung carcinoma-loaded mice were randomly divided into 2 groups(control and treatment group, n=6 in each group). Cisplatin (DDP, 25 mg/ kg) and saline were injected intragastricaly everyday to the treatment and control group, respectively. Tumor volume and weight were detected everyday and 18F-FLT MicroPET scans were performed at 0, 2, 5, 9, 14 d. The MicroPET results showed that after the second ad-ministration, the tumor uptake of treatment group decreased 21. 28%, from (4. 91 ± 0. 71)%ID/g to (3. 87±0. 61)%ID/g, while tumor volume was significantly decreased until 9 d (P<0. 01). Compared with traditional method, MicroPET can detect much earlier and more accurate efficacy of antitumor agents.关键词
18F-FLT/MicroPET/顺铂/药效评价Key words
18F-FLT/microPET/cisplatin/efficacy evaluation分类
医药卫生引用本文复制引用
王燕,颜成龙,郭先伟,李新平,梁克勇,唐玲玲,黄丽蓉..18F-FLT MicroPET评估顺铂对A549肺癌早期疗效反应的研究[J].同位素,2011,24(z1):80-84,5.基金项目
国家自然科学基金资助项目(81101077,81171399) （81101077,81171399）
卫生部核医学重点实验室开放课题(KF200982,KF201112) （KF200982,KF201112）
