同位素2012，Vol.25Issue(1)：21-26,6.
11C-(-)间羟基麻黄素的合成及Micro PET显像
Radiosynthesis of 11C-meta- (-) Hydroxyephedrine and Micro PET Imaging
摘要
Abstract
11C-meta-(-)Hydroxyephedrine(11C-(-) HED, 11C-HED) is a radiotracer suitable for mapping human sympathetic nervous system for heart failure, heart transplantation, arrhythmia and diabetic autonomic neuropathy and imaging tumors of the adrenal marrow. 11C-HED was synthesized by direct N-methylation of metaraminol with the 11C-methy-iodine and purified by semi-preparative reversed-phase HPLC(Semi-HPLC). The uptake of myocardium was studied by co-injection of 11C-(-)HED with metaraminol in mice. The results showed that the by-products can be reduced with 11C-methy-iodine as the N-methylation a-gents. HPLC purification was started with 3% EthOH in 0. 24 moL/L NaH2PO4, and then switched to 10% EthOH in 0. 24 moL/L NaH2PO4 after 10 min, through this process theprecursor was speparated from 11C-HED. Results of biodistribution showed that the uptake of 11C-HED in heard was blocked by co-injection of the metaraminol at 2 mg/kg, but the ID/'o/g of adrenals was increased. Micro PET imaging showed that the heart can be visualized at 10 and 30min postinjection, but the uptake of myocardium was decreased and the washout was speeded after co-injection of the precursor. The chemical and radiochemical purity of -C-(-)HED can be improved by using 3% EthOH in 0. 24 moL/L NaH2PO4 and then switching to 10% EthOH in 0. 24 moL/L NaH2PO4 as the HPLC mobile phase.关键词
11C-(-)间羟基麻黄素/交感神经系统/间羟胺/PETKey words
11C-(-)HED/ sympathetic nervous system/ metaramino/ PET分类
能源科技引用本文复制引用
尹大一,刘健,张晓军,徐白萱,田嘉禾,张锦明..11C-(-)间羟基麻黄素的合成及Micro PET显像[J].同位素,2012,25(1):21-26,6.基金项目
核能开发科技项目(2009-1228) （2009-1228）
