武汉工程大学学报2012，Vol.34Issue(1)：14-18,5.DOI:10.3969/j.issn.1674-2869.2012.1.004
雷贝拉唑合成研究进展
Progress on synthesis of rabeprazole
肖艳华 1冯睿杰1
作者信息
- 1. 武汉工程大学化工与制药学院,绿色化工过程教育部重点实验室,湖北省新型反应器与绿色化学工艺重点实验室,湖北武汉430074
- 折叠
摘要
Abstract
The synthesis of the key intermediate of the second generation proton pump inhibitor rabeprazole by using the first 4-bit chloride method, the first 2-bit sulfide method and the first 2-bit acylation method, 2-[ [ ( [4-( 3-methoxypropoxy ) -3-methyl-2-pyridinyl ] -methyl ) thio ] -1 H-benzimidazole, and employing various oxidations to perform the sulfide oxidation, were described in detail. The advantages and shortcomings of these methods of yield and by-products were analyzed and compared together, and the improvement of concise and green technology was proposed.关键词
雷贝拉唑钠/合成/工艺改进Key words
rabeprazole/ synthesis/ improvement of technology分类
医药卫生引用本文复制引用
肖艳华,冯睿杰..雷贝拉唑合成研究进展[J].武汉工程大学学报,2012,34(1):14-18,5.
