西安交通大学学报（医学版）2012，Vol.33Issue(2)：152-155,160,5.
中国西北地区汉族人群5-羟色胺2A受体启动区多态性与心境障碍发病、性别、症状、自杀的相关性
Association of 5-HTR2A promoter region gene polymorphisms with episode, gender, symptoms and suicidality of affective disorder in northwest Chinese Han population
摘要
Abstract
Objective To explore the association of 5-HTR2A (-1438A/G) promoter region gene polymorphisms with episode, gender, suicidality and subtypes of affective disorder in northwest Chinese Han population. Methods Polymerase chain reaction (PCR) was used to detect distribution frequency of serotonin 2A receptor promoter region polymorphisms of 160 affective disorder patients (patient group) and 160 normal people (control group) ; PCR and sequencing technique were applied to detect the association of serotonin 2A receptor gene polymorphisms with episode, gender, suicidality and subtypes of affective disorder of the patient group and the control group. Results There were significant differences in 5-HTR2A genotypes and the alleles between the patient group and the control group. The frequencies of G/G (38.7% vs. 34.4%) and A/G (47.5% vs. 40.6%) genotypes and G alleles (62. 5% vs. 54. 7%) were significantly higher in the patient group than in the control group (all P<0.05). There was no significant difference between men and women patients (P>0.05). No significant difference was found between patients with bipolar disorder (depressive phase) and unipolar depression. Affective disorder patients with or without suicidality behavior did not differ significantly in frequency of the genotypes or that of the alleles (P>0.05). There was no significant difference in distribution frequency of 5-HTR2A genotypes and alleles between men and women affective disorder patients with suicidality behavior (P>0.05). Conclusion 5-HTR2A gene polymorphisms are related to the episode of affective disorder, especially unipolar depression, in northwest Chinese Han population. A/G and G/G may be the susceptibility genotypes of affective disorder, and G allele may be the susceptibility gene.关键词
精神障碍/基因/聚合酶链反应/5-羟色胺2A受体/基因多态性Key words
mental disorder/ gene/ polymerase chain reaction/ 5-HTR2A/ gene polymorphism分类
医药卫生引用本文复制引用
柳文华,张兰,殷宏,罗建勋..中国西北地区汉族人群5-羟色胺2A受体启动区多态性与心境障碍发病、性别、症状、自杀的相关性[J].西安交通大学学报（医学版）,2012,33(2):152-155,160,5.基金项目
甘肃省科技厅计划-自然基金(No.1010RJZA104) （No.1010RJZA104）
