中国组织工程研究2012，Vol.16Issue(11)：1919-1922,4.DOI:10.3969/j.issn.1673-8225.2012.11.005
碱性成纤维细胞生长因子对乙醇中毒大鼠ATP酶及抗氧化作用的影响
Effects of basic fibroblast growth factor on adenosine triphosphatase activity and antioxidation of alcoholism rat models
摘要
Abstract
BACKGROUND: Basic fibroblast growth factor(bFGF) has multiple biological activities, and has positive effect on the recovery oftissue trauma. But the effect of bFGF against alcoholism has not been reported.OBJECTIVE: To study the effect of bFGF on the activities of adenosine triphosphatase (ATPase) and superoxide dismutase(SOD) and malondialdehyde (MDA)in cerebral cortex and liver tissue of alcoholism rat model.METHODS: The alcoholism rat models were established by perfusing stomach with alcohol. Thirty Wistar rats were randomlydivided into three groups. Normal saline group and bFGF treatment group were injected with normal saline and bFGF,respectively, at 60 days after modeling; Alcoholism model group was treated with no intervention. Another 10 rats without alcoholserved as control group.RESULTS AND CONCLUSION: The activities of ATPase and SOD in the cerebral cortex and livertissue of alcoholism modelgroup were significantly decreased than those in the control group, but the content of M DA was significantly higher than that inthe control group (P＜0.05). After bFGF intervention, the activities of ATPase and SOD in the cerebral cortex and livertissuewere significantly increased compared with the normal saline group and alcoholism model group, but the content of MDA wassignificantly decreased (P＜0.05-0.01). bFGF can increase the activities of ATPase and the antioxidative ability of brain tissue inalcoholism model rats. The bFGF can protect the brain and liver of rats against alcoholism.关键词
碱性成纤维细胞生长因子/酒精中毒/ATP/酶/超氧化物歧化酶/丙二醛分类
医药卫生引用本文复制引用
黄俊杰,王彩冰,何显教,黄丽娟,黄彦峰,梁祚仁,阳秀英,黎昀,赵善民..碱性成纤维细胞生长因子对乙醇中毒大鼠ATP酶及抗氧化作用的影响[J].中国组织工程研究,2012,16(11):1919-1922,4.基金项目
广西教育厅科研项目(200810LX045). （200810LX045）
