中国组织工程研究2012，Vol.16Issue(11)：1994-1998,5.DOI:10.3969/j.issn.1673-8225.2012.11.022
酵母膏联合氧嗪酸钾构建高尿酸血症模型大鼠继发的心血管病变
Development of secondary cardiovascular disease in hyperuricemia model rats induced by yeast extract combined with oteracil potassium
迪丽达尔·希力甫 1赵平 1宋丽娟 1尼加提·热合木 2张向阳1
作者信息
- 1. 新疆医科大学第一附属医院心血管中心,新疆维吾尔自治区,乌鲁木齐市,830000
- 2. 新疆医科大学病理教研室,新疆维吾尔自治区,乌鲁木齐市,830000
- 折叠
摘要
Abstract
BACKGROUND: The construction of hyperuricemia animal models is an important tool to study the relationship betweenhyperuricemia, renal disease and cardiovascular disease.OBJECTIVE: To establish hyperuricemia rat model using yeast extract combined with different doses of oteracil potassium and toexplore the optimal dose for model establishment.METHODS: Rats were continuously treated with yeast extract or yeast extract combined with various doses of oteracil potassiumby intragastric feeding or intraperitoneal injection for 28 days to establish rat hyperuricemia model.RESULTS AND CONCLUSION: Compared with the control group, there was significant increase in serum levels of uric acid in thegroups of intragastric feeding with yeast extract alone, yeast extract combined with 50-200 mg/kg oteracil potassium orintraperitoneal injection with yeast extract combined with 50-100 mg/kg oteracil potassium; however, no remarkable effect on ratkidney, heart or artery was found. A continuously high level of serum uric acid and morphological and pathological changes in ratkidney, heart and arteries were detected when the dosage of oteracil potassium intraperitoneally injected combined with yeastextract was maximized to 200 mg/kg. These findings indicate that intraperitoneal injection of yeast extract combined with200 mg/kg oteracil potassium is an optimal dosage for the construction of a persistent and stable hyperuricemia animal model; it isa favorable model for the study of pathological damages related to secondary cardiovascular diseases caused by hyperuricemia.关键词
尿酸/高尿酸血症/模型/氧嗪酸钾/酵母膏/心血管病变分类
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迪丽达尔·希力甫,赵平,宋丽娟,尼加提·热合木,张向阳..酵母膏联合氧嗪酸钾构建高尿酸血症模型大鼠继发的心血管病变[J].中国组织工程研究,2012,16(11):1994-1998,5.
