中国组织工程研究2012，Vol.16Issue(11)：2059-2062,4.DOI:10.3969/j.issn.1673-8225.2012.11.037
创面修复"TIME"原则及其意义
"TIME" principles and its clinical significance in wound repair
摘要
Abstract
BACKGROUND: While the cellular and molecular mechanisms of wound healing have been understood gradually and theexperiences of wound bed management have been accumulated, the importance of wound bed preparation to wound repair hasrecently attracted more attention.OBJECTIVE: To fully analyze the mechanisms of wound healing, various influence factors and their effects in this progress.METHODS: An on line search of CNKI and PubMed databases was performed for articles published between 1994 and 2011,using key words of “TIME principles, wound bed preparation, wound healing” in Chinese and English, respectively. The clinicalapplication principles and outcomes of wound healing were analyzed.RESULTS AND CONCLUSION: A total of 498 papers were collected, and 24 of them were included according to inclusive criteria.TIME is the initials of four principles in wound bed management. T means to remove the necrotic tissue. I means to control theinfection and to reduce the inflammation. M means to keep the wound moisture under normal condition for the granulation tissuegrowth and re-epithelialization. E means to remove non migrating epidermis at the edge of wound. As a valuable guidance tool forwound management, the TIME concept has been applied to clinical practice, and has been widely appreciated by clinicans.关键词
创伤愈合/溃疡/清创/慢性创面/创面分析分类
医药卫生引用本文复制引用
徐媛,刘宏伟..创面修复"TIME"原则及其意义[J].中国组织工程研究,2012,16(11):2059-2062,4.基金项目
受国家重点基础研究发展规划资助项目(2005CB522603) （2005CB522603）
国家自然科学基金资助项目(30772257,30973127) （30772257,30973127）
中央高校基本科研业务费专项资金资助项目(21611416)等资助. （21611416）
