中国组织工程研究2012，Vol.16Issue(14)：2585-2588,4.DOI:10.3969/j.issn.1673-8225.2012.14.024
人脐带间充质干细胞治疗失代偿期肝硬化的近期效果
Short-term effects of human umbilical cord-derived mesenchymal stem cells in treatment of patients with decompensated cirrhosis
摘要
Abstract
BACKGROUND: Umbilical cord-derived mesenchymal stem cells (UCMSCs) can differentiate into hapatocyte-like cells. OBJECTIVE: To investigate short-time clinical effects of UCMSCs transplantation in treatment of patients with decompensated cirrhosis.METHODS: Thirty patients with decompensated cirrhosis were involved. Eighteen patients in the control group were treated with conventional therapy, while twelve patients in the transplantation group were treated with UCMSCs transplantation via hepatic artery based on conventional therapy.RESULTS AND CONCLUSION: After transplantation, albumin level in the transplantation group showed an ascend trend and had a significant increase (P < 0.05) compared with the control group from 2 weeks to 12 weeks of transplantation. Meanwhile, both alanine aminotransferase and prothrombin time levels began to decrease at 2 weeks after transplantation and were significantly lower than those of the control group (P < 0.05) from 8 weeks to 12 weeks of transplantation. In contrast to the controls, the level of total bilirubin in the transplantation group showed an ascend trend and had a significant increase (P < 0.05) from 4 weeks to 12 weeks of transplantation. The differences in clinical symptoms and signs between the two groups were not significant (P > 0.05). The transplantation of UC-MSCs via hepatic artery is effective in short time for treatment of patients with decompensated cirrhosis.关键词
肝硬化/脐带/间充质干细胞/失代偿期/肝动脉/移植分类
医药卫生引用本文复制引用
张月凡,李楠,翟俊山,姜丽君,曹建宁..人脐带间充质干细胞治疗失代偿期肝硬化的近期效果[J].中国组织工程研究,2012,16(14):2585-2588,4.基金项目
吴阶平医学基金会资助项目(320.6710.10001). （320.6710.10001）
