中国组织工程研究2012，Vol.16Issue(14)：2637-2640,4.DOI:10.3969/j.issn.1673-8225.2012.14.034
脑肿瘤干细胞的研究现状
Research progress in brain tumor stem cells
王欣欣 1刘季平2
作者信息
- 1. 内蒙古科技大学包头医学院病理教研室,内蒙古自治区包头市,014010
- 2. 内蒙古北方重工集团职工医院神经外科,内蒙古自治区包头市,014030
- 折叠
摘要
Abstract
BACKGROUND: Research in recent years has discovered some stem cell-like cells exist in brain tumors, which have theproperties of endless cell proliferation, uncontrolled self-renewal and multi-directional differentiation, and they are called as braintumor stem cells. Brain tumor stem cells play a key role in the progress of tumorigenesis, growth, invasion, metastasis andrecurrence.OBJECTIVE: To conclude and explore the current studies on brain tumor stem cells.METHODS: A computer-based search of Pubmed Database was performed to retrieve relevant articles about brain tumor andbrain tumor stem cells published from January 1977 to July 2011. Books on stem cells and brain tumor stem cells were alsoretrieved. The data were selected primarily, and 32 articles related to brain tumor stem cells were selected.RESULTS AND CONCLUSION: Brain tumor stem cells exist in malignant brain tumor, and they are the origin of the occurrence,development, metastasis and recurrence of malignant brain tumor. Brain tumor stem cells express CD133, Nestin protein andABC transporter in malignant brain tumors. Recently, a simple method has been obtained to isolate brain tumor stem cells. Theproportion of CD133 positive tumor stem cells is positively correlated with the severity of malignant brain tumors, which can beused as a diagnostic indicator of prognosis.关键词
脑肿瘤/脑肿瘤干细胞/CD133/Nestin蛋白/综述文献分类
医药卫生引用本文复制引用
王欣欣,刘季平..脑肿瘤干细胞的研究现状[J].中国组织工程研究,2012,16(14):2637-2640,4.
