中国组织工程研究2012，Vol.16Issue(15)：2665-2668,4.DOI:10.3969/j.issn.1673-8225.2012.15.002
骨关节炎时内源性细胞因子及基质金属蛋白酶抑制因子1对关节软骨的影响
Effect of endogenous cytokines and tissue inhibitor of matrix metalloproteinase 1 on the articular cartilage of osteoarthritis patients
摘要
Abstract
BACKGROUND: Studies have found that the cytokine participates in the formation of osteoarthritis by influencing balance between catabolism and anabolism of articular cartilage matrix. Interleukin 1β (IL-1β) and tissue inhibitors of matrix metalloproteinase 1 (TIMP-1) play an important role. OBJECTIVE: To investigate the effect of endogenous cytokines, IL-1β and TIMP-1, on cataplasia of articular cartilage of osteoarthritis. METHODS: Thirty-seven patients with knee osteoarthritis were studied who were treated in the Fifth Affiliated Hospital of Harbin Medical University during 2006-06/2009-09. Extraction of synovial fluid and separation of smooth and shining synovial membrane tissues were performed during microscopic examination in patients. Ten specimens of normal synovial fluid and smooth and shining synovial membrane tissue were used as control. RESULTS AND CONCLUSION: In the osteoarthritis patients, the levels of IL-1β and TIMP-1 in synovial fluid and synovial membrane tissue were all significantly higher than those in the normal synovial fluid, the synovial fluid concentration of IL-1β and TIMP-1 were positively related to the severity of osteoarthritis. These findings demonstrate that the level of IL-1β and TIMP-1 are related with osteoarthritis and cartilage degradation.关键词
基质金属蛋白酶抑制因子1/骨关节炎/白细胞介素1β/关节液/滑膜组织/关节软骨退变分类
医药卫生引用本文复制引用
赵敬河,杨秋云,王冰..骨关节炎时内源性细胞因子及基质金属蛋白酶抑制因子1对关节软骨的影响[J].中国组织工程研究,2012,16(15):2665-2668,4.基金项目
黑龙江省卫生厅资助项目(2004-043). （2004-043）
