中国组织工程研究2012，Vol.16Issue(15)：2848-2850,3.DOI:10.3969/j.issn.1673-8225.2012.15.041
脑缺血再灌注动物模型的血脑屏障损伤
Blood brain barrier injury in animal models after cerebral ischemia-reperfusion
摘要
Abstract
BACKGROUND: Cerebral ischemia-reperfusion results in the breakdown on blood brain barrier, leading to cerebral hemorrhage, brain edema and the aggravated damage of brain tissue. OBJECTIVE: To summarize and analyze the effects of associated molecules on the blood-brain barrier damage in animal models after cerebral ischemia-reperfusion. METHODS: A computer-based online search of PubMed (2001-01/2011-12) and CNKI (2006-01/2011-12) was performed for related articles with the keywords of “cerebral ischemia-reperfusion injury, blood brain barrier permeability” in English and Chinese, respectively. Researches on cerebral ischemia-reperfusion injury and blood brain barrier permeability were included. Repetitive studies were excluded. A total of 17 articles were retained. RESULTS AND CONCLUSION: The molecules associated with blood brain barrier after cerebral ischemia-reperfusion injury were summarized from many aspects, such as inflammatory infiltration, matrix metalloproteinases hydrolysis and aquaporin opening. The blood-brain barrier function is regulated by many factors and many links. The 3-hour time window of the blood brain barrier opening after cerebral ischemia-reperfusion injury is crucial for the emergency treatment of ischemic penumbra. The later repairing effect of matrix metalloproteinase may provide basis for the drug innovation.关键词
脑缺血再灌注/血脑屏障/缺血性脑血管病/炎症因子/基质金属蛋白酶分类
医药卫生引用本文复制引用
张宇玲,蔡文杰..脑缺血再灌注动物模型的血脑屏障损伤[J].中国组织工程研究,2012,16(15):2848-2850,3.基金项目
上海高校选拔培养优秀青年教师科研专项基金(slg08032). （slg08032）
