西南国防医药2012，Vol.22Issue(5)：496-498,3.DOI:10.3969/j.issn.1004-0188.2012.05.009
燃煤型砷中毒患者肺功能损害与病理改变的特征
Characteristics of lung functional lesion and pathological variation in patients undergoing coal - burning arsenic poisoning
摘要
Abstract
Objective To discuss the characteristics of the lung functional lesion in patients undergoing coal - burning arsenic poisoning and its pathological foundation. Methods The lung function of 98 patients with chronic coal - burning arsenic poisoning was detected by Autospiro pal lung function tester from MINATO Company of Japan. The pathological results of pulmonary tissue in 22 ones receiving lung biopsy were analyzed. Results Among the 98 patients, the lung disfunction rate was 82. 7% ( 81/98 ), in which restrictive ventilation function disturbance accounted for 86. 4%( 70/81 ); mixed ventilation function disturbance accounted for 8. 6% ( 7/81 ); obstructive ventilation function disturbance accounted for 4. 9%( 4/81 ). Increasing of fibrous tissue in pulmonary interstitium, thickening of pulmonary interstitium, infiltration of leukomonocyte and neutrophihc granulocyte, light - middle degree of edema in alveolar wall and obvious thickening of alveolar wall could be observed under the optical microscope. Type Ⅱ alveolar epithelial cell degeneration, necrosis, shedding and decreasing of number were observed under the electron microscope, and hyperplasia of collagen fiber was obvious. Conclusion Restrictive ventilation function disturbance is the main clinical type of lung functional changes in patients undergoing coal - burning arsenic poisoning, which has close correlation with the pathological changes such as fibroplasias in pulmonary interstitium,thickening of pulmonary interstitium,decreasing of elasticity in lung issue caused by edema of alveolar wall and damage in type Ⅱ alveolar epithelial cell.关键词
燃煤型砷中毒/肺功能/病理/特征Key words
coal - burning arsenic poisoning/lung function/pathology/characteristics分类
医药卫生引用本文复制引用
杨运旗,陈吉,孙兰英,陈宁,张爱华..燃煤型砷中毒患者肺功能损害与病理改变的特征[J].西南国防医药,2012,22(5):496-498,3.基金项目
国家自然科学基金资助项目(30060077) （30060077）
全军医学基金资助项目(01MA048) （01MA048）
