摘要
Abstract
Objective To discuss the changes of plasma Ghrelin, CRP, IL - 8 and TNF - α before and after the adjunctiYe therapy with diammonium glycyrrhizinate( DG )in patients with severe acute pancreatitis( SAP). Methods 100 patients with SAP were randomly divided into two groups :DG adjunctive treatment group and normal treatment group. APACHE - Ⅱ scoring was made at the time of administration( 0 d )and 3 d after the treatment. The changes of hemodiastase, lipase, plasma Ghrelin, CRP, IL - 8 and TNF - α were observed at the time of administration, 1 and 3 d after the treatment. Other 50 health adults were chosen as the control group. Results The APACHE - Ⅱ scores of DG adjunctive treatment group and normal treatment group all decreased significantly 3 d after the treatment, and the score of the former group decreased more obviously( P < 0. 05 ). The contents of hemodiastase, lipase, plasma Ghrelin,CRP,IL - 8 and TNF - α in the two groups all decreased progressively,and those of DG adjunctive treatment group decreased more obviously( P < 0. 05 ). Conclusion DG has adjunctive therapeutic effects on SAP. The contents of plasma Ghrelin, CRP, IL - 8 and TNF - α level has correlation with the severity of SAP.关键词
甘草酸二铵/急性坏死性胰腺炎/Ghrelin/CRP/IL-8/TNF-αKey words
diammonium glycyrrhizinate/ severe acute pancreatitis/ Ghrelin/ CRP/ IL - 8/ TNF - α分类
医药卫生
