新医学2012，Vol.43Issue(1)：13-16,4.DOI:10.3969/g.issn.0253-9802.2012.01.005
CagA+幽门螺杆菌根除前后对冠心病患者hsCRP、ox-LDL、PAF及血栓素B2的影响
Effects of Helicobacter pylori CagA + eradication on ox-LDL, hsCRP, PAF and TXB2 in patients with coronary heart disease
摘要
Abstract
Objective; To investigate the effects of Helicobacter pylori (Hp) cytotoxin associated gene A + (CagA+ ) eradication on oxidized-low density lipoprotein (ox-LDL), high sensitive C reactive protein (hsCRP), platelet- activating factor (PAF) and thromboxane B2 (TXB2) in patients with coronary heart disease. Methods; Fifty-seven coronary heart disease (CHD) patients infected with Hp + CagA+ (eradication therapy group) and 57 CHD patients without Hp infection (control group) were recruited the study. The Hp eradication therapy and placebo therapy were given to patients in eradication therapy group and control group, respectively. The follow-up period was 6 months. Serum ox-LDL, hsCRP, PAF and TXB2 were recorded before and after treatment. Results; Signifi-cant reduction of hsCRP, ox-LDL, PAF and TXB2 were revealed in erdication therapy group at the end of study (P <0. 05). Conclusion; Hp + CagA+ eradication alleviates serum hsCRP, ox-LDL, PAF and TXB2 in CHD patients infected with Hp + CagA+.关键词
冠状动脉粥样硬化性心脏病/幽门螺杆菌/C反应蛋白/氧化低密度脂蛋白/血小板活化因子/血栓素B2Key words
Coronary heart disease/ Helicobacter pylori/ C reactive protein/ Oxidized-low density lipopro-tein/ Platelet-activating factor/ Thromboxane B2引用本文复制引用
程颖,冯燕玲,李劲草,林桂雄,吴钰燕,卓裕丰,张鹏,黄冰生,解强..CagA+幽门螺杆菌根除前后对冠心病患者hsCRP、ox-LDL、PAF及血栓素B2的影响[J].新医学,2012,43(1):13-16,4.基金项目
广州市番禺区科技局资金资助(2007-Z-79-1) （2007-Z-79-1）
