新医学2012，Vol.43Issue(1)：30-33,4.DOI:10.3969/g.issn.0253-9802.2012.01.010
1型糖尿病酮症酸中毒并发非甲状腺疾病病态综合征者3型脱碘酶mRNA水平研究
Study of iodothyronine deiodinase type Ⅲ mRNA level in patients with type 1 diabetes and ketoacidosis complicated with euthyroid sick syndromes
商跃云 1黄乐 1孙桂香 1吕玲 1赵彦1
作者信息
摘要
Abstract
Objective; To investigate the iodothyronine deiodinase type ffl (D3) mRNA level in patients with type 1 diabetes mellitus ( Tl DM) and diabetic ketoacidosis ( DKA) complicated with euthyroid sick syndromes (ESS). Methods; Blood samples of 28 cases with T1DM and DKA complicated with ESS were collected 24 hours after being diagnosed, 7 and 14 days after DKA being corrected. Meanwhile, 30 cases with matched age and sex, and without infection, thyroid disease, anoxia, operation or fasting, were selected as control group. Serum T3, T4 , FT3, FT4 and TSH levels were measured by RIA, while D3 mRNA level was assessed by real time polymerase chain reaction (Real-time PCR). Results; T3, FT3 and FT4 concentrations of DKA patients were significantly lower than those of control group, but recovered 14 days after DKA corrected except for T3. D3 mRNA level of DKA patients was significantly higher than that of control group. Although decline of D3 mRNA was revealed after DKA corrected , no complete recovery was observed. Conclusion: The alteration of D3 mRNA may contribute to ESS pathogen-esis in patients with T1DM and DKA.关键词
糖尿病,1型/糖尿病酮症酸中毒/3型脱碘酶/正常甲状腺病态综合征Key words
Type 1 diabetes mellitus/ Diabetic ketoacidosis/ Iodothyronine deiodinase type HI/ Euthyroid sick syndromes引用本文复制引用
商跃云,黄乐,孙桂香,吕玲,赵彦..1型糖尿病酮症酸中毒并发非甲状腺疾病病态综合征者3型脱碘酶mRNA水平研究[J].新医学,2012,43(1):30-33,4.
