应用化学2012，Vol.29Issue(2)：144-148,5.DOI:10.3724/SP.J.1095.2012.00126
N-取代-3,5-双苄叉基-哌啶-4-酮的合成及其抗癌活性的测定
Synthesis and Anti-tumor Activity of N-( Substituted benzyl ) -3,5-bis (benzylidene) -4-piperidones
摘要
Abstract
A series of novel N-( substituted benzyl)-3, 5-bis ( benzylidene)-4-piperidones (8a ~ 8j ) were synthesized uisng substituted benzylamines as precursors via a series of Michael addition, Dieckmann condensation, hydrolysis decarboxylation and Aldol condensation. The structures were confirmed by 1H NMR, IR, MS and elemental analysis. The preliminary biological activity tests by MTT assay indicated that some of the target compounds had good antiproliferative activities against K562, MDR-MB-231 and HO8910PM cells, and therefore showed potential anti-tumors bioactivity.关键词
N-取代哌啶酮/合成/抗癌活性/MTT法Key words
N-substituted-piperidone/synthesis/anti-tumor/MTT assay分类
化学化工引用本文复制引用
单振国,薛思佳..N-取代-3,5-双苄叉基-哌啶-4-酮的合成及其抗癌活性的测定[J].应用化学,2012,29(2):144-148,5.基金项目
国家自然科学基金(201042010)和上海市教委重点科技攻关项目(09391212100)资助项目 （201042010）
