中国病理生理杂志2012，Vol.28Issue(4)：643-648,6.DOI:10.3969/j.issn.1000-4718.2012.04.012
EGFR与c-Kit蛋白的表达与鼻咽癌原发瘤的进展相关
Protein expression of EGFR and c-Kit is associated with primary tumor progression in nasopharyngeal carcinoma
摘要
Abstract
AIM: To investigate the protein expression of 2 receptor tyrosine kinases , epidermal growth factor receptor ( EGFR) and c - Kit, in non - keratinizing nasopharyngeal carcinoma ( NPC) and to analyze the relationship of that with the clinicopathological parameters . METHODS: Ninety - five samples of stage II and III non - keratinizing NPC biopsies were collected from the Department of Pathology , Sun Yat - sen University Cancer Center. The 10% formalin -fixed paraffin - embedded biopsy blocks were re - sectioned. Besides HE routine staining , immunohistochemistry was performed for detecting the expression of EGFR , c - Kit, latent membrane protein 1 ( LMP1) and Ki - 67. RESULTS : The protein expression rates of EGFR and c - Kit were 70. 53% (67/95) and 63. 16% (60/95), respectively. The expression score of EGFR was positively correlated with that of c - Kit protein (P < 0. 05). They were both correlated with T staging ( EGFR ,P < 0. 05 ; c - Kit, P < 0. 01). Furthermore, the staining intensities of EGFR and c - Kit proteins were also correlated with T staging ( EGFR, P < 0. 05 ; c - Kit, P < 0. 01). CONCLUSION: The proteins of EGFR and c - Kit are usually expressed in non - keratinizing NPC cells. The immunoreactive scores of these 2 receptor tyrosine kinases are positively correlated with each other. Either the expression rate or the immunoreactive intensity of EGFR and c - Kit proteins is correlated with primary tumor progression. Immunohistochemical staining of EGFR or c - Kit protein in NPC biopsies could be recognized as an insight into further gene analysis for target therapy .关键词
表皮生长因子受体/c-Kit/鼻咽肿瘤Key words
Epidermal growth factor receptor/c-Kit/Nasopharyngeal neoplasms分类
医药卫生引用本文复制引用
奚少彦,吴秋良,宗永生,雍娟娟,梁建中,侯景辉,卢佳斌..EGFR与c-Kit蛋白的表达与鼻咽癌原发瘤的进展相关[J].中国病理生理杂志,2012,28(4):643-648,6.基金项目
华南肿瘤学重点实验室鼻咽癌单病种基金资助项目(No.303040736005) （No.303040736005）
