首页|期刊导航|中国海洋湖沼学报（英文版）|Characterization of flounder (Paralichthys olivaceus) FoxD5 and its function in regulating myogenic regulatory factor
中国海洋湖沼学报（英文版）2012，Vol.30Issue(2)：286-294,9.DOI:10.1007/s00343-012-1080-4
Characterization of flounder (Paralichthys olivaceus) FoxD5 and its function in regulating myogenic regulatory factor
Characterization of flounder (Paralichthys olivaceus) FoxD5 and its function in regulating myogenic regulatory factor
摘要
Abstract
As one member of winged helix domain transcription factors,FoxD5 was reported to be atrunk organizer.Recent study showed that zebrafishfoxd5 is expressed in the somites.To further understand the function of FoxD5 in fish muscle development,the FoxD5 gene was isolated from flounder.Its expression pattern was analyzed by in situ hybridization,while its function in regulating myogenic regulatory factor,MyoD,was analyzed by ectopic expression.It showed that flounder FoxD5 was firstly expressed in the tailbud,adaxial cells,and neural plate of the head.In flounder embryo,FoxD5 is expressed not only in forebrain but also in somite cells that will form muscle in the future.When flounder FoxD5 was over-expressed in zebrafish by microinjection,the expression of zebrafish MyoD in the somites was reduced,suggesting that FoxD5 is involved in myogenesis by regulating the expression of MyoD.关键词
flounder/FoxD5/muscle/over-expression/in situ hybridization/myogenic regulatory factorKey words
flounder/FoxD5/muscle/over-expression/in situ hybridization/myogenic regulatory factor引用本文复制引用
TAN Xungang,ZHANG Yuqing,SUN Wei,ZHANG Peijun,XU Yongli..Characterization of flounder (Paralichthys olivaceus) FoxD5 and its function in regulating myogenic regulatory factor[J].中国海洋湖沼学报（英文版）,2012,30(2):286-294,9.基金项目
Supported by the Natural Science Foundation of Shandong Province,China (No.Y2008E12) and the National Basic Research Program of China (973 Program) (No.2010CB126304) （No.Y2008E12）
