中国康复2012，Vol.27Issue(1)：3-5,3.DOI:10.3870/zgkf.2012.01.001
两种治疗方法对兔膝骨关节炎软骨MMP-1的影响
Effect of Two Therapies on MMP-1 Expression in Cartilage of Rabbits with Knee Osteoarthritis
摘要
Abstract
Objective: To observe the effect of ultrasound therapy vs electroacupuncture on the expression of MMP-1 in the cartilage of rabbit knee osteoarthritis model. Methods: Forty New Zealand rabbits were randomly divided into the normal group, the model group, the ultrasound group and the electroacupuncture group. Any group except the normal group was given straight bit left knee plaster casts to create osteoarthritis. The changes in the pathological morphology and the expression of MMP-1 were observed. Results; By Mankin's score, the degree of pathological lesion in model group was severer than other groups (P<0. 01). The expression levels of MMP-1 in model group were higher than other groups (P<0. 01). There was no significant difference between ultrasound group and electroacupuncture group. Conclusions: Both ultrasonic treatment and electroacupuncture can effectively reduce the expression of MMP-1 in the cartilage, and can be used to treat knee knee osteoarthritis.关键词
骨关节炎/超声波/电针/MMP-1Key words
osteoarthritis/ ultrasound/ electroacupuncture/ MMP-1分类
医药卫生引用本文复制引用
李卫平,胥方元,蹇睿,刘曦..两种治疗方法对兔膝骨关节炎软骨MMP-1的影响[J].中国康复,2012,27(1):3-5,3.基金项目
四川省卫生厅科研基金资助项目(050075) （050075）
