中国农业科学2012，Vol.45Issue(2)：369-375,7.DOI:10.3864/j.issn.0578-1752.2012.02.020
诱导性多能干细胞的研究及应用
Study and Application of Induced Pluripotent Stem Cells
摘要
Abstract
The study of induced pluripotent stem cells (iPS cells/iPSCs) has become hot spot of stem cell research since the mouse embryonic fibroblast and tail tip fibroblast were successfully reprogrammed to iPSCs. Compared with embryonic stem cells, iPS cells have many advantages, such as simple operation and high stability. The iPSCs has potential values in both the fundamental study of biology and clinical application. iPS cells' application would be very useful in various fields, for example, creating genetic models for human diseases, obtaining transgenic animals for organ transplantation therapies, improving animal production traits and disease resistance, as well as for bio-pharmaceuticals and so on. In addition, the application of iPSCs would have a great significance for solving the long-standing problems of stem cell research ethical issues and immune rejection. With the combination of gene therapy and cell transplantation therapies, the iPSCs research findings have been applied to animal disease models and transgenic animals. And iPS cells technology elicits a great promise for patient-specific cell therapy and development of gene targeted drugs. Furthermore, the technology also provides a novel platform for the research of iPS cells reprogramming mechanism and pathological process of human disease. However, at the present stage iPSCs' research is just beginning and there is still much work to do before iPSCs can be considered as a clinically reliable cell source. The research progress, current situation and future application prospects of iPSCs technology were discussed in the paper.关键词
重编程/胚胎干细胞/诱导性多能干细胞Key words
reprogramming/ embryonic stem cells/ induced pluripotent stem cells引用本文复制引用
苗向阳,陈晓瑛..诱导性多能干细胞的研究及应用[J].中国农业科学,2012,45(2):369-375,7.基金项目
国家"863"计划项目(2008AA10Z140)、转基因生物新品种培育科技重大专项(2009ZX08008-004B,2008ZX08008-003)、国家自然科学基金项目 (30571339)、中国农业科学院创新基金项目(2004-院-1) （2008AA10Z140）
