中国全科医学2012，Vol.15Issue(3)：281-284,4.
PINCH蛋白在垂体腺瘤中的表达及其意义
Expression and Significance of PINCH Protein in Pituitary Adenoma
摘要
Abstract
Objective To investigate the expression of PINCH protein in pituitary adenoma and to evaluate the relationship between the expression of PINCH protein and pituitary adenoma. Methods 50 patients with pituitary adenoma from January 2005 to January 2007 were involved into the study. The expression of PINCH protein of tissue samples from 37 invasive pituitary adenomas ( invasive group ), 13 noninvasive pituitary adenomas ( noninvasive group ) and 15 normal brain ( control group ) were examined by immunohistochemical method. Results The positive expression rate of PINCH protein was 56. 8% ( 21/37 ) in 37 cases of invasive pituitary adenomas and 23. 1% ( 3/13 ) in 13 cases of noninvasive pituitary adenomas and 0 ( 0/15 ) in normal brain cases. There were statistically significant differences in positive expression rate of PINCH protein of pituitary adenomas between level IH to IV and level I to II ( x = 6. 05, P < 0. 05 ) . There were no statistically significant differences in positive expression rate of pituitary adenomas between patients with different sex, age and histological type of pituitary adenomas ( P > 0. 05 ) . The expression of PINCH protein was positively correlated with the grade of Knosp ( r =0. 9974, P <0. 01 ). Conclusion Positive expression of PINCH protein in invasive pituitary adenoma is high, and it indicates that PINCH protein may play an important role in the invasion and prognosis of pituitary adenoma. But PINCH protein expression is not obviously correlated with patients' gender, age and histological type of pituitary adenomas.关键词
垂体肿瘤/PINCH蛋白/免疫组织化学/肿瘤侵润Key words
Pituitary neoplasms/ PINCH protein/ Immunohistochemistry/ Neoplasm invasiveness分类
医药卫生引用本文复制引用
赵强,王洪,顾平,史彦芳,宋颖,王铭维,朱振龙,孙晓峰..PINCH蛋白在垂体腺瘤中的表达及其意义[J].中国全科医学,2012,15(3):281-284,4.基金项目
保定市科学研究与发展计划项目(08ZF007) （08ZF007）
