摘要
Abstract
In the signaling network, mitogen - activated protein kinase ( MAPK ) signaling pathway plays an extremely important role. The abnormal activation of MAPK will lead to the loss of cell differentiation and apoptosis function, resulting in malignant transformation, abnormal proliferation, tumorigenesis, enhancement of the invasive ability and ultimately tumor metastasis. Extracellular signal - regulated kinase ( ERK ) is an important member in MAPK family. Its signaling pathway is involved in the core of the signaling networks that regulate cell growth, development and division. The basic steps of the signaling have been clear to us. It follows the reaction of the three enzymatic cascades of MAPKs, namely: the upstream activating protein→ MAPK kinase kinase ( MAPKKK ) → MAPK kinase ( MAPKK ) → the MAPK. In the ERKs pathway, Ras is an upstream activating protein;Raf is MAPKKK, MAPK / ERK kinase ( MEK ) as MAPKK, ERK or MAPK, which is Ras - Raf - MEK - ERK pathway. It is one of the most important pathways of the epidermal growth factor receptor ( EGFR ) signaling pathway and the major regulator of cell proliferation and growth. MAPK plays an important role especially in the occurrence of breast cancer development, invasion and metastasis in malignant tumors.关键词
乳腺肿瘤/丝裂原活化蛋白激酶/丝裂原激活蛋白激酶激酶类Key words
Breast neoplasms/Mitogen - activated protein kinase/Mitogen - activated protein kinase kinases分类
医药卫生
