中国全科医学2012，Vol.15Issue(9)：969-971,3.
乳腺癌术后逆向调强放疗致放射性肺损伤的剂量学研究
Dosimetric Study on Reverse Intensity-Modulated Radiotherapy Induced Radioactive Lung Damage in Patients with Breast Cancer
贺春钰 1张建庆 2木妮热·木沙江 1司马义力·买买提尼牙孜1
作者信息
- 1. 830011,新疆乌鲁木齐市,新疆医科大学附属肿瘤医院乳腺放疗科
- 2. 新疆维吾尔自治区人民医院放疗科
- 折叠
摘要
Abstract
Objective To investigate the dosimetric factors associated with radiation - induced lung damage in patients with breast cancer treated by reverse intensity -modulated radiotherapy. Methods 113 breast cancer patients who underwent reverse intensity - modulated radiotherapy were divided into lung damage group and non - lung damage group. Several clinical factors including age, emphysema, chronic bronchitis and dosimetric factors were analyzed by univariate and multivariate logistic regression analysis. Results The median follow - up time was 27. 5 months. The incidence of radiation - induced lung damage was 15. 9%. Univariate analysis showed that the thickness of chest wall, V5, V10 , V13, V15, mean lung dose ( MID ) were all significantly higher in lung damage group than those in non - lung damage group ( P < 0. 05 ) . Multivariate analysis showed that V10 and V13 were independent factors for radiation - induced lung damage. When using V10 < 33% as a cut - off to predict radiation - induced lung damage, the sensitivity and specificity were 94. 4% and 84. 2%. When using V13 <23% as a cut - off to predict radiation - induced lung damage, the sensitivity and specificity were 94. 4% and 80. 0%. Conclusion V10 and V13 are valuable indicators for predicting radiation - induced lung damage. In reverse intensity - modulated radiotherapy, it is not safe to spread small dose of radiation to a larger body.关键词
乳腺肿瘤/放射疗法/放射性肺损伤Key words
Breast neoplasms/Radiotherapy/Radiation - induced lung damage分类
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贺春钰,张建庆,木妮热·木沙江,司马义力·买买提尼牙孜..乳腺癌术后逆向调强放疗致放射性肺损伤的剂量学研究[J].中国全科医学,2012,15(9):969-971,3.
