中国全科医学2012，Vol.15Issue(9)：974-977,4.
北京部分社区人群血糖与超敏心肌肌钙蛋白T的相关性研究
Association between Blood Glucose Levels and High-Sensitivity Cardiac Troponins T in Community-Based Population in Beijing Area
摘要
Abstract
Objective To investigate the correlation between blood glucose levels and high - sensitivity cardiac tro-ponins T (hs - cTnT} in community - based population without coronary heart disease (CHD) by using hs - cTnT as measuring indicator for myocardial injury. Methods 1 365 subjects without CHD were recruited and were divided into diabetes mellitus ( DM ) group, impaired glucose regulation ( IGR ) group and normal glucose tolerance ( NGT ) group. The medical history, anthropometry, laboratory measurements including total cholesterol ( TC ), triglyceride ( TG ), low - density lipoprotein cholesterol ( LDL - C ), high - density lipoprotein cholesterol ( HDL - C ), fasting blood glucose ( FBG ), 2 hours postprandial blood glucose ( 2 hPG ), estimated glomerular filtration rate ( eGFR ) high - sensitivity C - reactive protein ( hs - CRP ), hs - cTnT were detected. Results Compared with NGT group and IGR group, both detectable rate ( hs - cTnT ^ 3 ng/L ) and elevated rate ( hs - cTnT≥13. 3 ng/L ) of hs - cTnT were significantly higher in DM group ( P <0. 05 ) . Even after adjusting age, sex, hypertension, current smoking, BMI, SBP, DBP, eGFR, serum levels of TG, HDL-C, LDL-C, FBG, 2 hPG and hs -CRP, the detectable rate of hs - cTnT [ OR = 1.22, 95%CI(1.04, 1.44), P =0.017 ] and elevated rate of hs - cTnT [OR = 1. 29, 95% CI ( 1. 04, 1.61), P = 0. 021] were still higher in DM group compared with NGT group. Multivariable stepwise regression analysis displayed that positive correlations existed between multiple cardiovascular risk factors and hs - cTnT, and FBG was one of the independent risk factors for hs - cTnT. Conclusion hs - cTnT has varied distributions in community - based population with different blood glucose levels. Both detectable rate and elevated rate of hs - cTnT were increased significantly in diabetic population, hs - cTnT was related to multiple risk factors of cardiovascular event. FBG was the independent risk factor for hs - cTnT elevation.关键词
肌钙蛋白T/糖尿病/因素分析,统计学Key words
Troponin T/Diabetes mellitus/Factor analysis, statistical分类
医药卫生引用本文复制引用
郑瑾,叶平,骆雷鸣,肖文凯,许如意,吴红梅..北京部分社区人群血糖与超敏心肌肌钙蛋白T的相关性研究[J].中国全科医学,2012,15(9):974-977,4.基金项目
北京市首都医学发展科研基金重点支持项目(2009-2038) （2009-2038）
