摘要
Abstract
Objective To discuss the application value and correlation of the detection of D - dimer, Cystatin C and immunoglobulin levels in the diagnosis of early kidney injury in Henoch - Schonlein Purpura ( HSP ) patients. Methods 80 patients with HSP were divided into HSP normal type group ( 46 cases ) and HSP kidney injury type group ( 34 cases ). Simultaneously , 60 physical examination children were randomly chosen as control group. The levels of D - dimer, Cysc C and immunoglobulin ( IgA, IgG, IgM ) were detected in the three groups. Results Levels of D - dimer, Cysc C and IgA between the three groups showed statistically significant differences ( P < 0. 05 );IgG and IgM levels between the three groups showed no statistically significant difference ( P >0. 05 );the levels of D - dimer, Cysc C and IgA in the two HSP groups were significantly increased compared with control group ( P < 0. 05 );the levels of D - dimer, Cysc C and IgA in HSP kidney injury type group were significantly increased compared with HSP normal type group ( P <0. 05 ) . D - dimer was positively correlated to Cysc C ( r =0. 81, P < 0. 05 );D - dimer was positively correlated to IgA ( r = 0. 55 , P < 0. 05 );Cysc C level was positively correlated to IgA ( r = 0. 68, P < 0. 05 ) . Conclusion The occurrence and development of HSP is a complicated process with multiple factors involved. D - dimer, Cysc C and immunoglobulin levels are valuable in the diagnosis of HSP, especially in the patients with early kidney injury. Detection of these indexes at early stage and timely preventive treatment, which should be clinically recommended and applied, is of great importance to protect the organ function and improve the prognosis.关键词
紫癜,过敏性/D-二聚体/胱抑素C/免疫球蛋白类Key words
Purpura, Schonlein - Henoch/D-dimer/Cystatin C/Immunoglobulins分类
医药卫生
