中国全科医学2012，Vol.15Issue(9)：1010-1014,5.
切除修复交叉互补基因1和着色性干皮病基因多态性与晚期非小细胞肺癌铂类药物化疗敏感性的关系研究
Relationship between ERCC1 and XPD Genetic Polymorphism and Sensitivity of Platinum-Based Chemotherapy in Advanced Non-Small Cell Lung Cancer
摘要
Abstract
Objective To investigate the relationship between genetic polymorphism of excision repair cross - complementing ( ERCC1 ) and xeroderma pigmentosum group D ( XPD ) and platinum - based chemotherapy in advanced non - small cell lung cancer ( NSCLC ) . Methods Genetic polymorphisms of ERCC1 118 C/T, C8092A and XPD Asn312Asp, Lys751Gln were detected by PCR - RFLP method in 130 patients with advanced NSCLC who received platinum - based chemotherapy and the relationship between genetic polymorphisms of ERCC1 and XPD and chemotherapy sensitivity was analyzed. Results After two chemotherapy cycles, the overall response rate is 33. 8% ( 44/130 ), including 44 PR ( 33. 8% ), 54 SD ( 41. 6% ) and 32 PD ( 24. 6% ) . The ERCC1 118 C/T +T/T carriers were 3. 300 times as sensitive to the chemotherapy as the C/C genotype [ 95% CI ( 1. 104, 9. 864 ), P =0. 003 ] . The XPD Asp312Asn and Lys751Gln ( or Gln751Gln ) carriers were 3. 922 times as sensitive to the chemotherapy as the other types [ 95% CI ( 1. 320, 11. 649 ), P = 0. 010 ] . The ERCC1 118 C/T ( or T/T ), XPD Asp312Asn and Lys751Gln ( or Gln751Gln ) polymorphism carriers were 3. 571 times as sensitive to the chemotherapy as the ER-CC1 118 C/C, XPD Asp312Asp and Lys751Lys polymorphism carriers [ 95% CI ( 1. 082, 11. 793 ), P =0. 032 ] . The effective rate of chemotherapy of the patients with A - C haplotype were significantly increased compared with other haplotypes ( P = 0.039) .Conclusion There is close relationship between polymorphism in ERCC1 118C/T and polymorphisms in XPD Asp312Asn, Lys751Gln and response of patients with advanced NSCLC receiving platinum - based chemotherapy.关键词
癌,非小细胞肺/切除修复交叉互补基因1/着色性干皮病基因/多态性,单核苷酸/抗肿瘤联合化疗方案Key words
Carcinoma, non - small cell lung/Excision repair cross - complementing 1/Xeroderma pigmentosum group D/Polymorphism, single nucleotide/Antineoplastic combined chemotherapy protocols分类
医药卫生引用本文复制引用
王小杰,许崇安,张晔,李琳,刘艳..切除修复交叉互补基因1和着色性干皮病基因多态性与晚期非小细胞肺癌铂类药物化疗敏感性的关系研究[J].中国全科医学,2012,15(9):1010-1014,5.基金项目
辽宁省自然科学基金(20082084) （20082084）
