中国全科医学2012，Vol.15Issue(10)：1112-1114,3.
肝硬化患者血清微量元素、免疫功能特点及相关性研究
Characteristics of Trace Elements and Immune Function in Patients with Hepatic Cirrhosis and Correlativity Analysis
泽塔多吉 1吕洪敏 2齐玉梅 3肖慧娟 3李晓爽3
作者信息
- 1. 300070天津市,天津医科大学三中心临床医学院
- 2. 西藏昌都地区人民医院
- 3. 天津市第三中心医院
- 折叠
摘要
Abstract
Objective To study the relationship between trace elements and immune function of patients with hepatic cirrhosis. Methods The level of the five serum trace elements in 52 patients with hepatic cirrhosis and 30 controls were detected by using Trace Element Detector, and the frequency of T -lymphocyte subsets in peripheral blood was detected by using Flow Cy-tometry. Results Compared with the control group, in the group of cirrhosis patients the serum Zn, Fe, Cr, Se levels were lower, and the serum Cu level was higher, especially at the decompensated stage ( P < 0. 05 ); CD3 , CD4, NK cell levels in peripheral blood were lower, especially at the decompensated stage ( P <0. 05 ). Linear correlation analysis showed: and CD3 , CD4, NK cell levels were negatively correlated with serum Cu level, but positively correlated with serum Zn level ( P <0. 05 ). Logistic regression analysis showed that Zn [ OR = 42. 023, 95 % CI ( 1. 164, 1 516. 474 ), P = 0. 041 ] and Cu [ OR = 69.429, 95% CI (0.942, 5 114.612), P=0.048] were the relative risk factors for cirrhosis. Conclusion Apart from con-ventional therapy of protecting liver function, the detection and correction serum trace elements, immune function have important positive significance for assessing the condition and treatment of patients with hepatic cirrhosis.关键词
微量元素/免疫功能/肝硬化Key words
Trace elements/ Immune function/ Liver cirrhosis分类
医药卫生引用本文复制引用
泽塔多吉,吕洪敏,齐玉梅,肖慧娟,李晓爽..肝硬化患者血清微量元素、免疫功能特点及相关性研究[J].中国全科医学,2012,15(10):1112-1114,3.
