中国全科医学2012，Vol.15Issue(11)：1222-1225,4.
宁夏回族人群脂联素水平及基因单核苷酸多态性与冠心病相关性研究
Correlation of Single Nucleotide Polymorphism of Adiponectin Gene with Coronary Artery Disease in Hui Ethnic Group in Ningxia
摘要
Abstract
Objective To study Adiponectin ( APN ) plasma level and the correlation of its single nucleotide gene polymorphism ( SNP45T/G and SNP276G/T ) with coronary heart disease ( CHD ) in Hui ethnic group in Ningxia. Methods A total of 193 Hui patients were divided into two groups based on the coronary angiography and the clinical data: coronary heart disease ( CHD ) group ( n = 95 ) and normal control group ( n = 98 ). Enzyme - linked immunosorbent assay ( ELISA ) and polymer-ase chain reaction - restriction fragment length polymorphism ( PCR - RFLP ) were used to detect the plasma APN level and the gene polymorphism of its two sites. Results Compared with the normal control group, the plasma APN level in CHD group was reduced. The distribution frequencies of SNP +45 TG + GG genotype and G allele in CHD group were significantly higher, and the distribution Frequencies of SNP +276TG + TT genotype and T allele were also significantly higher ( P <0. 05 ). The plasma APN level of SNP +45TG + GG genotype was significantly lower than that of TT genotype and the plasma APN level of SNP + 276TG + TT genotype was significantly lower than that of GG genotype ( P <0. 05 ). Conclusion The plasma APN level is low in Hui CHD patients. The distribution frequencies of SNP +45TG + GG genotype and G allele in Hui CHD patients may increase and the distribution frequencies of SNP + 276TG + TT genotype and T allele may decrease.关键词
回族/冠心病/脂联素/基因多态性Key words
Hui nationality/ Coronary disease/ Adiponectin/ Gene polymorphism分类
医药卫生引用本文复制引用
沈佳,陈芳,刘志军,杨锐英..宁夏回族人群脂联素水平及基因单核苷酸多态性与冠心病相关性研究[J].中国全科医学,2012,15(11):1222-1225,4.基金项目
宁夏回族自治区自然科学基金项目(NZ09109) （NZ09109）
