中国全科医学2012，Vol.15Issue(11)：1250-1253,4.
嗜麦芽窄食单胞菌医院感染特点及耐药性分析
Stenotrophomonas Maltophilia Infection in Hospital Environment:Its Characters and Drug Resistance
摘要
Abstract
Objective To analyze the characters and drug resistance of nosocomial stenotrophomonas maltophilia infections which took place in our hospital during recent two years. Our purpose is to provide a basis for the infection control and the clinical rational antibiotic use. Methods Disc diffusion method ( NCCLS currently recommended methods ) was used to detect the drug resistance of 50 strains of stenotrophomonas maltophilia isolated from 40 patients to 24 kinds of antibiotics. Homology of the isolates were submitted to molecular typing using pulsed - field gel electrophoresis ( PFGE ). Results These infections of stenotrophomonas maltophilia mainly occurred in lower respiratory tract, most of which were mix infections in patients mainly above 50. SMA was very susceptible to cefepime - sulbactam, gatifloxacin, levofloxacin, ofloxacin and cefoperazone - sulbactam, but was resistant to most of the antibiotics. The resistance rates to ceftriaxone, cefuroxime, cefoxitin were up to 100. 0% . The resistance rates to imipenem, aztreonam, tetracycline, piperacilin and gentamycin were 92. 3% , 88.9%, 82.4%, 75.0% and 70. 0% , respectively. Most isolates displayed different PFGE profiles ( 17/21 ), among the clonal isolates, one pairs from the same hospital ward, the other from different wards in the same hospital. ConclusionThe genomic diversity and low clonality within the strains of SMA may be the reasons why patients are infected with SMA existing naturally in the hospital environment. Cefepime - sulbactam, gatifloxacin, levofloxacin, ofloxacin and cefoperazone - sulbactam are the effective drugs against the infections caused by S. Maltophilia.关键词
医院感染/嗜麦芽窄食单胞菌/多重耐药/流行病学调查Key words
Hospital infection/ Stenotrophomonas maltophilia/ Multidrug resistant/ Epidemiological survey分类
医药卫生引用本文复制引用
史利克,王悦,刘燕,任力,戚小敏,时东彦..嗜麦芽窄食单胞菌医院感染特点及耐药性分析[J].中国全科医学,2012,15(11):1250-1253,4.基金项目
河北省科技攻关计划项目(04276183) （04276183）
