摘要
Abstract
Objective To investigate the clinical curative effect of Huangkui capsule combined with reduced glutathi-one in the treatment of patients with chronic kidney disease. Methods 60 patients with chronic kidney disease in CKD2 and CKD3 stages were randomly divided into conventional group ( group A ), conventional treatment plus Huangkui capsule group ( group B ) and conventional treatment plus Huangkui capsule as well as reduced glutathione group ( group C ) . Group A: diet of low but quality protein, treatment for reducing blood pressure and anti - infection, dipyridamole 50 mg, three times per day, fosinopril 10 mg, two times per day. Group B: Huangkui capsule ( produced by Suzhong pharmaceutical factory in Jiangsu province ) was added to the treatment in addition to conventional treatment with each time 5 capsules, three times per day. Group C: reduced glutathione was added to the treatment in addition to the treatment of group B with each time 120 mg, once per day. The treatment course for each group was two months. 24 h urine protein, albumin, urea nitrogen, serum creatinine, urine NAG, RBP and beta 2 - MG were detected and compared before and after the treatment. Results After treatment, the 24 h urine protein of the three groups showed statistically significant difference ( P = 0. 045 ), and the 24 h urine protein of group C was significantly lower than that of group B(P<0. 01) . The levels of albumin, urea nitrogen and serum creatinine in the three groups showed no statistically significant differences ( P > 0. 05 ) . After treatment, the levels of urine NAG, BRP and beta 2 - MG showed statistically significant differences ( P < 0. 05 ), and the group C and group B also showed statistically significant differences ( P <0. 05 ). Conclusion Huangkui capsule combined with reduced glutathione can reduce urine protein, improve the function of uriniferous tubules, inhibit the fibrosis of uriniferous tubules and slow down the chronic kidney disease.关键词
慢性肾脏病/蛋白尿/黄葵胶囊/还原型谷胱甘肽Key words
Chronic kidney disease/ Proteinuria/ Huangkui capsule/ Reduced glutathione分类
医药卫生
