摘要
Abstract
Objective To investigate the relationship between serum uric acid ( UA ) level and carotid artery arteriosclerosis in patients with type 2 diabetes mellitus ( T2DM ). Methods Blood glucose, blood lipid, UA, hs - CRP and blood pressure of 347 T2DM patients ( male: 174, female: 173 ) were detected, and the BMI was calculated. High frequency ultrasound was used to detect IMT and plaques. The correlation between the level of UA and carotid artery disease was analyzed. Results ( 1 ) The serum UA levels in men were significantly higher than those in women ( P =0. 007 ). ( 2 ) The subjects of both male and female were divided into 3 groups respectively ( groups A, B and C ) according to carotid artery ultrasonometry IMT ( group A: IMT s; 0.09 mm; group B: 0.09 mm < IMT < 0. 13 mm; group C: IMT≥0. 13 mm or plaques formation). Inwomen, the serum UA levels of group B and group C were significantly higher than those of group A ( P <0. 05 ). But in men, there was no statistically significant difference in the 3 groups ( P > 0. 05 ). ( 3 ) After adjusting for age, duration of diabetes mellitus, HbA,c, smoking, LDL, systolic blood pressure, body mass index, total cholesterol, triglyceride and C -reactive protein ( CRP ), Logistic regression analysis showed that the serum UA level in women was an independent risk factor for carotid artherosclerosis and carotid artery IMT ( P =0.039 ). But in men, no relationship was found between serum UA and carotid artherosclerosis. ( 4 ) Spearman analysis showed that in women, serum UA was positively correlated with TG ( r =0. 390, P = 0. 000 ) and hs - CRP ( r =0. 159, P =0. 036 ), but was negatively correlated with HDL - C ( r = -0. 223 , P =0. 003 ). Serum UA was almost positively correlated with BMI ( r =0. 156, P =0. 051 ). Conclusion Serum UA level is a risk factor for carotid artherosclerosis in women with T2DM. Controlling body weight and improving lipids metabolism disorder may reduce the incidence of hyperuricemia in women.关键词
糖尿病,2型/颈动脉疾病/尿酸/高尿酸血症Key words
Diabetes mellitus, type 2/ Carotid artery diseases/ Uric acid/ Hyperuricemia
Diabetes mellitus, type 2/ Carotid artery diseases/ Uric acid/ Hyperuricemia分类
医药卫生
