中国全科医学2012，Vol.15Issue(14)：1600-1602,3.
单核细胞趋化蛋白-1-2518A/G基因多态性与急性心肌梗死的相关性研究
Correlation of MCP-1-2518 A/G Gene Polymorphism with Acute Myocardial Infarction
王秋波 1张蕴莉2
作者信息
- 1. 121001辽宁省锦州市,辽宁医学院
- 2. 辽宁医学院附属第一医院检验科
- 折叠
摘要
Abstract
Objective To investigate the correlation of MCP - 1 - 2518 A/G gene polymorphism with acute myocardi-al infarction ( AMI) in Chinese Han population in Liaoxi Province. Methods Totally 150 unrelated AMI inpatients in our department from September 2010 to June 2011 were selected as case group. Meanwhile, 159 healthy persons ( confirmed by physical check - ups ) during the same period were recruited as the controls. MCP - 1 genotype was detected by polymerase chain reaction - restriction fragment length polymorphism ( PCR - RFLP ). The serum level of MCP - 1 was determined by enzyme linked immunosorbent assay ( ELISA ). Results There was a significant difference in genotype distribution of three types of genes ( AA, AG, and GG ) between these two groups ( P <0. 01 ). The frequency distribution of A allele was significantly different from G allele ( P <0. 01 ). The distribution differences of serum level of MCP - 1 between the two groups, and between different genotypes in the case group were all significant ( P <0. 01 ). Conclusion The MCP - 1 -2518A/G gene polymorphism is associated with the pathogenesis of AMI, and G allele may be a genetic risk factor for AMI, although such relation may co - exist with the conventional risk factors.关键词
急性心肌梗死/趋化因子CCL-2/多态性,单核苷酸/单核细胞趋化蛋白Key words
Acute myocardial infarction/ Chemokine CCL2/ Polymorphism, single nucleotide/ MCP - 1分类
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王秋波,张蕴莉..单核细胞趋化蛋白-1-2518A/G基因多态性与急性心肌梗死的相关性研究[J].中国全科医学,2012,15(14):1600-1602,3.
