中国全科医学2012，Vol.15Issue(15)：1711-1714,4.
甲状腺微小乳头状癌雌激素受体的表达及临床意义
Expression and Significance of Estrogen Receptor in Papillary Thyroid Microcarcinoma
华天书 1王志强 2夏米西努尔·伊力克1
作者信息
- 1. 830011新疆乌鲁木齐市,新疆医科大学基础医学院生物学教研室
- 2. 武警新疆总队医院神经内科
- 折叠
摘要
Abstract
Objective To investigate the expression of estrogen receptor (ER) in papillary thyroid microcarcinoma ( PTMC) and to discuss its clinical value in the occurrence and development of PTMC. Methods Immunohistochemistry was used to detect the expression of ER in 24 cases of normal tissue , 60 cases of PTMC ( 27 cases in PTMC I group and 33 cases in PTMC Ⅱ group) and 76 cases of PTC. The expressions were analyzed after combining with clinicopathologic features. Results The posi-tive expressions of ER in PTMC II group and PTC group were significantly higher compared with that of the normal tissues (P < 0. 05 ). The positive expression of ER in PTMC I group was significantly lower compared with that of PTC group ( P < 0. 05 ). Among the patients with PTMC , the positive expression of ER all showed statistically significant differences between those who ≥ 45 years old and those who <45 years old, those who had primary lesion >0. 5 cm and those who had primary lesion ≤0. 5 cm, those who had diolame and those who had no diolame , those who had lymph node metastasis and those had no lymph node metas -tasis ( P < 0. 05 ). Conclusion ER is closely related to the occurrence and development of PTC. The expression of ER is corre -lated with the age, carcinoma diameter, diolame and lymph node metastasis of the PTMC patients.关键词
甲状腺肿瘤/甲状腺微小乳头状癌/受体,雌激素/免疫组织化学Key words
Thyroid neoplasms/Papillary thyroid microcarcinoma/Receptors,estrogen/Immunohistochemistry分类
医药卫生引用本文复制引用
华天书,王志强,夏米西努尔·伊力克..甲状腺微小乳头状癌雌激素受体的表达及临床意义[J].中国全科医学,2012,15(15):1711-1714,4.
