中国人兽共患病学报2012，Vol.28Issue(5)：509-512,4.
鄱阳湖区血吸虫尾蚴对吡喹酮敏感性的实验研究
Experiment study susceptibility of Schistosoma japonicum in cercariae stage to praziquantel around Poyang Lake area
摘要
Abstract
This study nas ained to monitor the current susceptibility of S. Japonicum in cercariae stage to praziquantel. The cercariae were e×posed in -5 × 10-5, 10-5, 5 × 10-6, 10-6, 5 × 10-7, and 10-7 mol/L praziquantel solution for 20,40,60,80, and 100min,and then the changes in the patterns of behavior,including swimming,contraction,tail shedding and death, were observed under a microscope. Results shown that during the observation, some of the cercariae were dead before tail shedding when it were e×posing in -5 × 10～° mol/L praziquantel solution, while all of the death of the cercariae occurred after the tail shedding when they were e×posed in 10-5, 5× 10 -6, 10 -6, -5 × 10 -7, and 10-7 mol/L praziquantel solution and mortality were always lower than the tail shedding rates of cercariae at the same time point. When the cercariae were e×posed in 10-6 mol/L praziquantel for 80min,the tail shedding rate of cercariae was 92. 2%(SD 1. 8%) ; when in 10-6 mol/L praziquantel for 100min, the tail shedding rate of cercariae was 97. 7% (SD 2. 7%). E×posing to 10-6 mol/L praziquantel for 20, 40, 60, 80, and 100min, the tail shedding rates of the cercariae between the groups of epidemic area had no significant difference (P = 0. 8-51), the tail shedding rates of the cercariae had significant difference in different time(P<0. 001). In conclusions, there was no significant difference in the responses to praziquantel at the cercariae stage among S. Japonicum isolates in the epidemic areas around the Poyang Lake. E×posing to 10-6 mol/L praziquantel for 80min or lOOmin, the tail shedding rates of the cercariae were stable.关键词
鄱阳湖区/日本血吸虫尾蚴/吡喹酮/敏感性/尾蚴断尾率Key words
Poyang Lake areas/ Schislosoma japonicum in cercariae stage/ praziquantel/ susceptibility/ tail shedding rates of the cercariae分类
医药卫生引用本文复制引用
付翠华,陈年高,戴建荣,汪伟,李洪军,高祖禄,刘红云,宁安..鄱阳湖区血吸虫尾蚴对吡喹酮敏感性的实验研究[J].中国人兽共患病学报,2012,28(5):509-512,4.基金项目
江西省科技能力与环境建设计划项目(No.2008DTK00800) （No.2008DTK00800）
