首页|期刊导航|中国神经再生研究（英文版）|Alpha-amino-3-hydroxy-5-methyl-4- isoxazolepropionic acid receptor antagonist inhibits apoptosis of retinal ganglion cells in a rabbit model of optic nerve injury

Alpha-amino-3-hydroxy-5-methyl-4- isoxazolepropionic acid receptor antagonist inhibits apoptosis of retinal ganglion cells in a rabbit model of optic nerve injury

Ruijia Wang Xinping Luan Yiti Mu Hongyu Jia Jingxuan Xu

中国神经再生研究（英文版）2012，Vol.7Issue(10)：731-735,5.

中国神经再生研究（英文版）2012，Vol.7Issue(10)：731-735,5.DOI:10.3969/j.issn.1673-5374.2012.10.002

Alpha-amino-3-hydroxy-5-methyl-4- isoxazolepropionic acid receptor antagonist inhibits apoptosis of retinal ganglion cells in a rabbit model of optic nerve injury

Ruijia Wang ¹Xinping Luan ¹Yiti Mu ¹Hongyu Jia ¹Jingxuan Xu¹

作者信息

1. Department of Neurosurgery, Second Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China
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摘要

Abstract

A rabbit model of traumatic optic nerve injury, established by occlusion of the optic nerve using a vascular clamp, was used to investigate the effects of alpha-amino-3-hydroxy-5-methyl-4- isoxazolepropionic acid receptor antagonist GYKI 52466 on apoptosis of retinal ganglion cells following nerve injury. Hematoxylin-eosin staining and a terminal deoxynucleotidyl transferase dUTP nick end labeling assay showed that retinal ganglion cells gradually decreased with increasing time of optic nerve injury, while GYKI 52466 could inhibit this process. The results demonstrate that following acute optic nerve injury, apoptosis of retinal ganglion cells is a programmed process, which can be inhibited by the alpha-amino-3-hydroxy-5-methyl-4- isoxazolepropionic acid receptor antagonist.

关键词

optic nerve injury/retinal ganglion cells/glutamate/alpha-amino-3-hydroxy-5-methyl-4- isoxazolepropionic acid receptor

Key words

optic nerve injury/retinal ganglion cells/glutamate/alpha-amino-3-hydroxy-5-methyl-4- isoxazolepropionic acid receptor

引用本文复制引用

Ruijia Wang,Xinping Luan,Yiti Mu,Hongyu Jia,Jingxuan Xu..Alpha-amino-3-hydroxy-5-methyl-4- isoxazolepropionic acid receptor antagonist inhibits apoptosis of retinal ganglion cells in a rabbit model of optic nerve injury[J].中国神经再生研究（英文版）,2012,7(10):731-735,5.

基金项目

The Foundation of Xinjiang Uygur Autonomous Region in China,No.200821137 （）

the National Natural Science Foundation of China,No.81160153. （）

中国神经再生研究（英文版）

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ISSN：1673-5374

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