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Telomerase expression in the glial scar of rats with spinal cord injury

Mingkun Yang Weibin Sheng Tao Xu Kai Huang Yanjiao Wang

中国神经再生研究（英文版）2012，Vol.7Issue(11)：810-814,5.

中国神经再生研究（英文版）2012，Vol.7Issue(11)：810-814,5.DOI:10.3969/j.issn.1673-5374.2012.11.002

Telomerase expression in the glial scar of rats with spinal cord injury

Mingkun Yang ¹Weibin Sheng ¹Tao Xu ¹Kai Huang ¹Yanjiao Wang²

作者信息

1. Department of Spinal Surgery, First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China
2. Department of Molecular Biology, Basic Medical College, Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China
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摘要

Abstract

A rat model of spinal cord injury was established using the weight drop method. A cavity formed 14 days following spinal cord injury, and compact scar tissue formed by 56 days. Enzyme-linked immunosorbent assay and polymerase chain reaction enzyme-linked immunosorbent assay results demonstrated that glial fibrillary acidic protein and telomerase expression increased gradually after injury, peaked at 28 days, and then gradually decreased. Spearman rank correlation showed a positive correlation between glial fibrillary acidic protein expression and telomerase expression in the glial scar. These results suggest that telomerase promotes glial scar formation.

关键词

spinal cord injury/glial scar/telomerase/astrocytes/glial fibrillary acidic protein

Key words

spinal cord injury/glial scar/telomerase/astrocytes/glial fibrillary acidic protein

引用本文复制引用

Mingkun Yang,Weibin Sheng,Tao Xu,Kai Huang,Yanjiao Wang..Telomerase expression in the glial scar of rats with spinal cord injury[J].中国神经再生研究（英文版）,2012,7(11):810-814,5.

基金项目

This project was funded by the National Natural Science Foundation of China,No.81060106. （）

中国神经再生研究（英文版）

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ISSN：1673-5374

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