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Remodeling of motor cortex function in acute cerebral infarction patients following human urinary kallidinogenase A functional magnetic resonance imaging evaluation after 6 months

Xuezhu Song Lixin Han Yan Liu

中国神经再生研究（英文版）2012，Vol.7Issue(11)：867-873,7.

中国神经再生研究（英文版）2012，Vol.7Issue(11)：867-873,7.DOI:10.3969/j.issn.1673-5374.2012.11.012

Remodeling of motor cortex function in acute cerebral infarction patients following human urinary kallidinogenase A functional magnetic resonance imaging evaluation after 6 months

Xuezhu Song ¹Lixin Han ²Yan Liu¹

作者信息

1. Department of Neurology, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou 510010, Guangdong Province, China
2. Magnetic Resonance Center of Guangzhou General Hospital of Guangzhou Military Command, Guangzhou 510010, Guangdong Province, China
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摘要

Abstract

A total of 29 patients were treated within 48 hours after acute subcortical cerebral infarction with Xuesaitong or Xuesaitong plus human urinary kallidinogenase for 14 days. Neurological deficits, activity of daily living, and evaluations of distal upper limb motor functions at the 6-month follow-up showed that patients treated with Xuesaitong plus human urinary kallidinogenase recovered better than with Xuesaitong alone. In addition, functional MRI revealed that activation sites were primarily at the ipsilesional side of injury in all patients. Human urinary kallidinogenase induced hyperactiva-tion of the ipsilesional primary sensorimotor cortex, premotor cortex, supplementary motor area, and contralesional posterior parietal cortex. Results showed that human urinary kallidinogenase improved symptoms of neurological deficiency by enhancing remodeling of long-term cortical motor function in patients with acute cerebral infarction.

关键词

cerebral infarction/functional magnetic resonance imaging/human urinary kallidino-genase/motor function remodeling/neural regeneration

Key words

cerebral infarction/functional magnetic resonance imaging/human urinary kallidino-genase/motor function remodeling/neural regeneration

引用本文复制引用

Xuezhu Song,Lixin Han,Yan Liu..Remodeling of motor cortex function in acute cerebral infarction patients following human urinary kallidinogenase A functional magnetic resonance imaging evaluation after 6 months[J].中国神经再生研究（英文版）,2012,7(11):867-873,7.

基金项目

This study was supported by the Science and Technology Program of Guangzhou,No.2006Z12E0119 （）

Guangzhou Science and Technology Key Project,No.122732961131543. （）

中国神经再生研究（英文版）

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ISSN：1673-5374

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