首页|期刊导航|中国神经再生研究（英文版）|Survivin small interfering RNA suppresses glioblastoma growth by inducing cellular apoptosis
中国神经再生研究（英文版）2012，Vol.7Issue(12)：924-931,8.DOI:10.3969/j.issn.1673-5374.2012.12.008
Survivin small interfering RNA suppresses glioblastoma growth by inducing cellular apoptosis
Survivin small interfering RNA suppresses glioblastoma growth by inducing cellular apoptosis
摘要
Abstract
A survivin small interfering RNA sequence specific for a human and mouse homogenous sequence was constructed. Survivin small interfering RNA could significantly inhibit glioma cell proliferation and induce apoptosis when it was transfected into either a human glioma cell line U251 or rat glioma C6 cells in vitro. In addition, treatment of rat orthotopic glioma models with survivin small interfering demonstrated the inhibition of glioma growth in vivo. Our experimental findings suggest that the use of RNA interference techniques to target the survivin sequence may be useful in the treatment of glioma.关键词
RNA interference/survivin/glioblastoma/apoptosisKey words
RNA interference/survivin/glioblastoma/apoptosis引用本文复制引用
Yanbo Liu,Chunming Miao,Zhenjiang Wang,Xin He,Weigao Shen..Survivin small interfering RNA suppresses glioblastoma growth by inducing cellular apoptosis[J].中国神经再生研究（英文版）,2012,7(12):924-931,8.基金项目
The study was supported by the Natural Science Foundation of Jilin Province,No.2011146,2012150 and the Natural Science Foundation of Jilin Technology Division,No.201133139 and 201032235. （）
