中国实用内科杂志2012，Vol.32Issue(2)：109-111,3.
绝经后妇女25羟基维生素D浓度及其与甲状旁腺素和骨转换指标关系548例研究
25-hydroxyvitamin D level and its correlation with parathyroid hormone and bone transforming parameters:analysis on 548 postmenopausal women
摘要
Abstract
Objective To determine the prevalence of 25-hydroxyvitamin D[25(OH)D] deficiency in postmenopausal women,and to explore its correlation with parathyroid hormone (PTH) and bone transforming parameters. Methods We screened 548 healthy postmenopausal women[mean age (63. 6 ±6. 5) years]from February 2010 to March 2010 in Shanghai. All subjects were allocated into severe vitamin D deficiency group ( < 24 nmol/L), vitamin D deficiency group (24 ~ <48 nmol/L) ,vitamin D shortage group (48 ~ < 72 nmol/L) and vitamin D sufficiency group ( ^72 nmol/L) based on the level of 25(OH)D. Fasting serum concentrations of 25(OH)D and PTH were tested in addition to bone transforming parameters,including beta degradation product of carboxyl-terminal telopeptide of type I collagen ( p-CTX) ,osteo-calcin (OC) and amino-terminal propeptide of type I collagen (P1NP); Results Of 548 cases, vitamin D was severely deficient in 184 cases (33. 6% ) ^deficient in 251 cases (45. 9% ) ,in shortage in 30 cases (5. 5% ) and sufficient in 82 cases (15. 0% ). Further analysis on age,body mass index,PTH and each bone transforming parameters among groups yielded unremarkable difference in the former two items. Following the decline in 25 (OH) D level was a gradual increase in PTH, p-CTX, OC and PI NP in vitamin D sufficiency group ( P < 0.01). An inverse association between 25 ( OH ) D and PTH and bone transforming parameters ( all P <0. 01.) was found. Conclusion Vitamin D deficiency is common among healthy pbst-menopausal women during winter in Shanghai. Attention should be attached to those with significantly increased serum PTH level and bone transforming parameters.关键词
骨质疏松,绝经后/25羟基维生素D/甲状旁腺素/骨转换指标Key words
osteoporosis, post menopausal/ 25 (OH) D/ parathyrioid gland/ bone turnover marbers分类
医药卫生引用本文复制引用
鲍春华,何进卫,柯耀华,张增,傅文贞,汪纯,张浩,岳华,章振林..绝经后妇女25羟基维生素D浓度及其与甲状旁腺素和骨转换指标关系548例研究[J].中国实用内科杂志,2012,32(2):109-111,3.基金项目
国家自然科学基金(81170803、81070692、81000360和30800387) （81170803、81070692、81000360和30800387）
上海市科委重大科技专题攻关项目(10D1950100) （10D1950100）
上海市科委自然科学基金(11ZR1427300) （11ZR1427300）
上海市卫生局新百人优秀学科带头人培养计划(XBR2011014) （XBR2011014）
