中国实用内科杂志2012，Vol.32Issue(2)：138-141,4.
慢性肾脏病229例25羟基维生素D浓度及影响因素分析
25 (OH)D and relevant factors in 229 chronic kidney disease patients
王宓 1邵茁 2王梅1
作者信息
- 1. 北京大学人民医院肾内科,北京100044
- 2. 中日友好医院检验科,北京100029
- 折叠
摘要
Abstract
Objective To investigate the prevalence rates of vitamin D shortage and deficiency as well as the relevant factors in non-dialysis patients with chronic kidney disease (CKD). Methods We recruited 229 non-dialysis patients with stage 1 to stage 5 non-nephrotic CKD in People's Hospital of Peking University from January 2009 to September 2010. Serum 25(OH)D level and other clinical parameters were examined,and the prevalence rates of vitamin D shortage and deficiency were analyzed. The independent predictors of vitamin D deficiency were identified using Logistic regression model. Results Serum 25(OH)D level was (30. 23 ± 13. 95) nmol/L. Vitamin D concentration gradually decreased following the progression of CKD. 169 patients (73. 80% ) were identified as having vitamin D deficiency. Remarkable distinction was found in prevalence rate of vitamin D deficiency at various stages of CKD in that higher prevalence rate tended to favor more advanced CKD stages (χ2 =18. 289, P = 0.001). Vitamin D deficiency differed ( P = 0. 025) in prevalence rate at various stages even excluding those with diabetes and after adjusting the age. Serum albumin, phosphorus and diabetes were independent predictors of vitamin D deficiency in non-dialysis patients with non-nephrotic CKD, as was indicated by Logistic regression model. Conclusion Patients with CKD have higher prevalence rate of vitamin D shortage and deficiency, which happed in the early stage of CKD. Serum albumin, phosphorus and diabetes are independent predictors of vitamin D deficiency in non-dialysis patients with non-nephrotic CKD.关键词
慢性肾脏病/血液净化/25羟基维生素DKey words
chronic kidney diseases/ non-dialysis /25 ( OH ) D分类
农业科技引用本文复制引用
王宓,邵茁,王梅..慢性肾脏病229例25羟基维生素D浓度及影响因素分析[J].中国实用内科杂志,2012,32(2):138-141,4.
